Research project «Comparison of the effectiveness of minimally invasive closure and traditional correction of ventricular septal defects in the early and late postoperative periods» (AP23488091)
Aim of the project: Development of an algorithm for selecting patients to perform correction of ventricular septal defect by occluder transventricular closure method with subsequent study of its effectiveness and safety in children.
Type of the study: single-center, open.
This study will include patients with a congenital ventricular septal defect who have undergone or are planning to have the defect repaired.
Two groups of patients will be studied:
1. Patients with a hybrid method of defect correction (n = 100)
2. Patients with defect correction under cardiopulmonary bypass (n = 100)
Patients in the study groups will be comparable in age and gender. Exclusion criteria were a combination of VSD with other heart defects and concomitant severe somatic diseases.
Expected results: This project is the first study in Kazakhstan on the comparative assessment of methods for minimally invasive closure of ventricular septal defects and traditional correction, with an assessment of effectiveness in the early and late postoperative periods. It is planned to develop a clinical protocol based on the results obtained and create an algorithm for selecting patients to perform correction of the ventricular septal defect with an occluder using the transventricular closure method. This technique is gentle, ensures maximum reduction in the trauma of the operation, without X-ray exposure, in addition, there are no consequences after artificial circulation, unlike the traditional technique. The duration of hospitalization and rehabilitation is reduced, a good cosmetic effect is achieved, and treatment costs are reduced. The specialists in clinics in Central Asia and Kazakhstan are deeply interested in mastering it, so the proposed research is of international significance. Publication of results in peer-reviewed journals included in Scopus and reports at world congresses will contribute to the dissemination of this technique, increasing the professional competencies of specialists at JSC NSMC, the effective development of Kazakhstani science, the development of cooperation with foreign colleagues and the attraction of foreign capital for further research on congenital heart defects.
Head of the project: Marassulov Shukhrat Iskanderovich, PhD, senior researcher
Team members:
Nurkeev Bakhytzhan Abidullaevich – PhD, Senior Physician PCD, JSC NSMC
Adilbekova Akkerbez Bakirkyzy – perfusionist, cardiac surgeon PCD, JSC NSMC
Tuyakbayev Bauyirzhan Myrzabayevich – cardiac surgeon PCD, JSC NSMC
Kerimkulov Amangeldi Kuanyshbekovich – Head of Department, Anesthesiology, reanimation and intensive treatment department PCD, JSC NSMC
Murzabayeva Sania Kurmanaevna – Senior Physician Anesthesiology, reanimation and intensive treatment department PCD, JSC NSMC
Akhmoldayeva Asiya Akylbekovna – children's cardiologist, JSC NSMC
Mayorov Rinat Akhatovich – radiology surgeon, interventional cardiologist PCD, JSC NSMC
Kuandykova Elmira Akmurzaevna – functional diagnostics physician PCD, JSC NSMC
Aldabergenov Erbol Nurlanuly – cardiac surgeon PCD, JSC NSMC
Doshchanova Rayhan Aralbaevna – head of the functional diagnostics department, interventional cardiosurgeon
Raimkhanov Timur Abdilevich – cardiac surgeon
Aitymbetova Gulmira Meirbekovna – economist
Talkymbayeva Aigul Barambaevna – accountant
Lookin Oleg Nikolaevich – science manager
Publications
Adilbekova A, Marassulov S, Baigenzhin A, Kozhakhmetov S, Nurkeyev B, Kerimkulov A, Murzabayeva S, Maiorov R, Kenzhebayeva A. Hybrid versus traditional method closure of ventricular septal defects in children. JTCVS Techniques, 2024, 24:137-144. DOI: 10.1016/j.xjtc.2024.01.015
Presentations at international conferences:
1) 28th AFCC ASEAN Federation of Cardiology Congress 2024 (08-10.11.2024, Singapore), poster presentation "Minimally invasive ventricular septal defect closure on a beating heart: 8 years of experience at our center" (presenter - Adilbekova A.B.)
2) International scientific and practical conference on pediatric cardiac surgery (11.02.2025, Shymkent), oral presentation "Hybrid method of VSD correction: pros and cons" (presenter - principal investigator Marasulov Sh.I.).
3) International Medical Scientific Forum "Mirrakhimov Readings" (17-19.04.2025, Bishkek, Kyrgyzstan), oral presentation "Correction of ventricular septal defect on a beating heart using a transventricular hybrid method: the experience of one center" (speaker - principal investigator Marasulov Sh.I., also served as the head of one of the forum's sections)
4) International Medical Scientific Forum "Mirrakhimov Readings" (17-19.04.2025, Bishkek, Kyrgyzstan), oral presentation "Advantages of anesthesia for children with a hybrid method of correcting ventricular septal defect" (speaker - Murzabaeva S.K.).
5) International Congress "Ultrasound in Medicine: Yesterday, Today, Tomorrow" (12-13.06.2025, Aktau), oral presentation "Transesophageal EchoCG in the surgical treatment of congenital heart disease" (speaker - principal investigator Marasulov Sh.I.)
Author's certificates:
1) Certificate of copyright for a literary work under number No. 58634 dated May 26, 2025: "Algorithm for selecting patients for a hybrid periventricular method for correcting ventricular septal defect in children" (authors: Marasulov Sh.I., Adilbekova A.B., Murzabaeva S.K., Mayorov R.A., Raimkhanov T.A.)
Theses defended during the project:
1) Member of the research team Adilbekova A.B. defended her dissertation in 2024 for the degree of Doctor of Philosophy (PhD) on the topic "Clinical and epidemiological aspects and prognostic factors in the treatment of ventricular septal defect in Kazakhstan."